Microalbuminuria, endocrinal metabolic disorders as predictors of hypertension

The present work aimed to study microalbuminuria, endocrinal and metabolic disorders that may predict hypertension. One hundred and thirty subjects were classified into three groups; group I patients with essential hypertension [50 patients], group II normotensive offsprings with family history of hypertension [50 subjects] and group III healthy normotensive subjects [30 subjects]. The study confirmed that many of the components of hypertension syndrome as metabolic abnormalities [increased total cholesterol, LDL-cholesterol, triglycerides and hyperhomocysteinemia], renal abnormalities [microalbuminuria] and endocrinal abnormalities [increased plasma insulin, norepinephrine, renin and endothelin levels] precede the onset of high blood pressure. So, early identification and treatment of them will have a more significant impact on the course of the disease

Endothelin-1 and nitric oxide in children with renal hypertension

Plasma and urinary endothelin-1[ET-1] and nitrate [NOx] as an index of nitric oxide generation were measured in 27 hypertensive children with renoparenchymal diseases, 15 normotensive children with renoparenchymal diseases and 20 healthy control children of matched age and sex. The mean value of plasma ET-1 concentration was significantly higher in hypertensive children with renoparenchymal diseases than both normotensive renal diseased children and normotensive healthy controls. Significant positive correlation was found between ET-1 levels and mean blood pressure in hypertensive children with renal diseases. The mean value of 24 hours urinary excretion of ET-1 was significantly higher in normotensive children with renal diseases than normotensive healthy controls, but significantly lower than hypertensive children with renal diseases. Significant increase in the plasma levels of NOx was observed among hypertensive renal diseased children than normotensive renal diseased children and normotensive healthy controls. Significant positive correlation was found between the levels of plasma ET-1 and plasma NOx in hypertensive renal diseased children